UVGI can be implemented by installing a series of lights within the air handling unit (AHU). All the air circulating within the facility is treated at a single point. This simplifies both installation and maintenance, as all UVGI equipment is in one central location.

UVGI can also be used within AHUs to eliminate mould and bacteria buildup (or biofilm) on the cooling coil and in the condensate water drip pan. If allowed to accumulate, biofilm releases potentially harmful bacteria and fungi spores into the AHU airstream and hardens to block the spaces between the cooling coils, restricting air flow and increasing energy consumption.

If the AHU based approach is not possible and there is sufficient room in the ceiling cavity, UV disinfection equipment can be integrated with the ductwork above the space. This adaptable approach can provide targeted disinfection for specific spaces like patient waiting rooms, classrooms, and areas with high humidity.

This approach can include ceiling-mounted, wall-mounted, or portable UVGI units. These units use fans to pull air in from the room, disinfect it, and recirculate it. This approach is common where the ceiling cavity is not large enough to accommodate disinfection or where supplemental disinfection is needed to clean areas with especially dense contamination.